Understanding Serzone: Risks of Liver Damage and Nefazodone Interactions

This blog post explores the risks associated with Serzone (nefazodone), particularly concerning liver damage and potential drug interactions. It emphasizes the importance of understanding these dangers and consulting with a healthcare professional or an attorney near you if you have experienced adverse effects.

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This blog post explores the risks of liver damage associated with Serzone (nefazodone) and highlights potential drug interactions and side effects. If you or a loved one has experienced adverse effects, consult a healthcare professional and a product liability attorney near you for guidance on your legal options.

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Understanding Serzone: Risks of Liver Damage and Nefazodone Interactions

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Jan 28, 2025 08:36 PM

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Understanding Serzone: Risks of Liver Damage and Nefazodone Interactions

Serzone (nefazodone) is an antidepressant used to treat major depression, anxiety, and related disorders. Manufactured by Bristol-Myers Squibb, it was approved by the FDA in 1994. Despite its initial success, Serzone was discontinued in the U.S. in 2004 due to safety concerns, particularly liver failure. This guide provides an overview of Serzone, its side effects, and legal considerations for those affected.

💡 For every post in this series, scroll down to “Related Posts.”

Serzone and Potential Drug Interactions

While Serzone is no longer available, its generic version, nefazodone, is still prescribed for major depressive disorder. Avoid nefazodone if you take:

Carbamazepine

Trazodone

Fluoxetine

Astemizole

Cisapride

Pimozide

Terfenadine

Consult your doctor before starting any new medication to avoid adverse interactions.

Side Effects of Serzone

Serzone differs from SSRIs and MAOIs, inhibiting serotonin and norepinephrine uptake. Common side effects include:

Dry mouth

Nausea

Drowsiness

Dizziness

Constipation

Seek medical attention if symptoms worsen or if you experience jaundice, loss of appetite, or abdominal pain.

Serious Risks: Liver Damage

In 2001, the FDA required a black box warning for Serzone due to severe liver damage risks. Reports indicated over 109 cases of liver failure, with some requiring transplants or resulting in death.

Serious Risks: Increased Depression and Suicidal Impulses

Antidepressants, including Serzone, have been linked to increased depression and suicidal thoughts. The FDA mandated a boxed warning on antidepressant labels to inform patients of these risks.

Talk to Your Healthcare Provider Before Taking Nefazodone

Before starting nefazodone, inform your doctor if you have:

Heart disease

High or low blood pressure

Seizures

Liver disease

Also, disclose any other medications or supplements you are taking.

What To Do if You're Hurt After Taking Serzone

If you experience adverse effects from nefazodone, seek medical attention and consult a product liability attorney. While Serzone has been off the market for years, legal claims for nefazodone may still be viable.

Conclusion

Serzone and nefazodone pose significant health risks, particularly liver damage. Understanding these risks and seeking legal advice can help affected individuals explore their options. If you experience health issues related to these drugs, consult a healthcare professional and a product liability attorney.

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